A Phase I Study of the Safety and Pharmacokinetics of Higher‐Dose Icotinib in Patients With Advanced Non‐Small Cell Lung Cancer
نویسندگان
چکیده
منابع مشابه
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15 صفحه اولA Phase I Study of the Safety and Pharmacokinetics of Higher-Dose Icotinib in Patients With Advanced Non-Small Cell Lung Cancer
LESSONS LEARNED This phase I study evaluated the maximum tolerated dose, dose-limiting toxicities, safety, pharmacokinetics, and efficacy of icotinib with a starting dose of 250 mg in pretreated, advanced non-small cell lung cancer patients. We observed a maximum tolerated dose of 500 mg with a favorable pharmacokinetics profile and antitumor activity.These findings provide clinicians with evid...
متن کاملEfficacy and safety evaluation of icotinib in patients with advanced non-small cell lung cancer.
OBJECTIVE To evaluate the efficacy and safety of icotinib hydrochloride in patients with advanced non-small cell lung cancer (NSCLC). METHODS A total of 89 patients with stage IIIB or IV NSCLC received icotinib at a dose of 125 mg administered 3 times a day. Icotinib treatment was continued until disease progression or development of unacceptable toxicity. RESULTS A total of 89 patients wer...
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ژورنال
عنوان ژورنال: The Oncologist
سال: 2016
ISSN: 1083-7159,1549-490X
DOI: 10.1634/theoncologist.2016-0256